Demethyldolastatin (MMAD)
MMAD
CAS: 203849-91-6
Molecular Formula: C41H66N6O6S
Demethyldolastatin (MMAD) - Names and Identifiers
Demethyldolastatin (MMAD) - Physico-chemical Properties
| Molecular Formula | C41H66N6O6S |
| Molar Mass | 771.06 |
| Density | 1.119±0.06 g/cm3(Predicted) |
| Boling Point | 906.1±65.0 °C(Predicted) |
| pKa | 13.81±0.46(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Use | Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate. |
| In vitro study | MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity. |
| In vivo study | The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats. |
Demethyldolastatin (MMAD) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.297 ml | 6.485 ml | 12.969 ml |
| 5 mM | 0.259 ml | 1.297 ml | 2.594 ml |
| 10 mM | 0.13 ml | 0.648 ml | 1.297 ml |
| 5 mM | 0.026 ml | 0.13 ml | 0.259 ml |
Last Update：2024-01-02 23:10:35
Demethyldolastatin (MMAD) - Reference Information
| biological activity | MMAD is a potent microtubule (tubulin) inhibitor, antibody-drug conjugate (ADCs). In the active molecule. |
Last Update：2024-04-09 21:48:26
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Product Name: MMAD Visit Supplier Webpage Request for quotationCAS: 203849-91-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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